Protein Purification
MilliporeSigma™ Calbiochem™ NF023
A suramin analog that acts as a selective and direct G-protein antagonist for α-subunits of the Go
MilliporeSigma™ Calbiochem™ Lenaldekar (LDK)
An inhibitor of T cell proliferation (IC50 = 3 μM in CD3+, CD4+, and CD8+ cells). Does not affect other cell types.
Novus Biologicals™ EV MiniSEC Columns
size exclusion chromatography (SEC) columns designed to isolate extracellular vesicles (EVs) from small volume samples
MilliporeSigma™ Calbiochem™ ER Export Inhibitor II, FLI-06
A cell-permeable compound that reversibly blocks cellular glycosylation and surface expression of Notch, APP, Klotho by blocking events prior to cargo assembly at the ER exit sites.
MilliporeSigma™ Calbiochem™ Caspase-1/4 Inhibitor, VX-765
A cell-permeable prodrug that upon conversion to its active form inhibits caspase-1 and 4 activity (Ki = 800 pM and 600 pM, respectively).
MilliporeSigma™ Calbiochem™ Smoothened Agonist, SAG
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
MilliporeSigma™ Calbiochem™ Glucokinase Activator III, Ro-28-1675
A cell-permeable activator of glucokinase. Exhibits in vivo glucose-lowering and insulin-releasing activity
MilliporeSigma™ Calbiochem™ AG 538
A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM).
MilliporeSigma™ Calbiochem™ DIDS, Disodium Salt
Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.
MilliporeSigma™ Calbiochem™ PDGFR Tyrosine Kinase Inhibitor V
The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ Glutaminase Inhibitor, Compound 968
A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10μM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cel
MilliporeSigma™ Calbiochem™ Memantine Hydrochloride
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.
MilliporeSigma™ Calbiochem™ Calpain-1 Substrate II, Fluorogenic
An internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides.
MilliporeSigma™ Calbiochem™ Glycogen Phosphorylase Inhibitor
The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.
MilliporeSigma™ Calbiochem™ NAE Inhibitor, MLN4924
NAE Inhibitor, MLN4924, CAS 951950-33-7, is an AMP mimetic that forms a NAE-catalyzed NEDD8 adduct, which acts as a tight-binding, ATP-competitive NAE inhibitor (IC50 = 4.7nM).